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Sildenafil is a potent and selective inhibitor of cGMP-particular phosphodiesterase type 5 (PDE5), that is accountable for degradation of cGMP from the corpus cavernosum. The molecular framework of sildenafil is comparable to that of cGMP and functions to be a competitive binding agent of PDE5 while in the corpus cavernosum, resulting in more cGMP
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